Bacterial vectors for the delivery of tumor antigens

• Published in: Methods in molecular biology (Clifton, N.J.) Vol. 1139; p. 429
• Main Authors: Wang, Yan, Toussaint, Bertrand, Le Gouëllec, Audrey
• Format: Journal Article
• Language: English
• Published: United States 2014
• Subjects: Animals; Antigens, Neoplasm - genetics; Antigens, Neoplasm - immunology; Cancer Vaccines - genetics; Cancer Vaccines - immunology; Cell Line; Cloning, Molecular; Genetic Vectors - genetics; Mice; Plasmids - genetics; Pseudomonas aeruginosa - genetics; Transformation, Genetic; Vaccination

The use of bacterial vectors, which offer ease of production and efficiency, has become an important mechanism for the delivery of protein antigens to antigen-presenting cells (APCs) in vivo. Proof of concept studies has been carried out utilizing different bacteria in various cancer models with som...