Synthesis of a novel tetrafluoropyridine-containing amino acid and tripeptide

The synthesis of a novel fluoropyridine-containing amino acid from pentafluoropyridine by a nucleophilic substitution process is reported. The orthogonal protecting groups can be manipulated and the fluoropyridine amino acid incorporated into a tripeptide.

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Bibliographic Details
Published inTetrahedron letters Vol. 54; no. 36; pp. 4865 - 4867
Main Authors Hudson, Alex S., Hoose, Alex, Coxon, Christopher R., Sandford, Graham, Cobb, Steven L.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 04.09.2013
Elsevier
Subjects
Amino acids
Chemistry
Chemistry, Organic
Novel amino acid
Pentafluoropyridine
Peptides
Physical Sciences
Science & Technology
Synthesis (chemistry)
Tetrahedrons
Novel amino acid
Peptides
Pentafluoropyridine
ALPHA-HELICAL PEPTIDES
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Summary:The synthesis of a novel fluoropyridine-containing amino acid from pentafluoropyridine by a nucleophilic substitution process is reported. The orthogonal protecting groups can be manipulated and the fluoropyridine amino acid incorporated into a tripeptide.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.06.124