The migration and attrition of Strongyloides ratti in naive and sensitized rats

Compressed organ autoradiography has been utilized to study the migration of the homogonic strain of Strongyloides ratti from the site of skin penetration to the gut. This transit is characterized by rapid disappearance of parasites from the cutaneous site of infection, followed by vascular dispersa...

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Bibliographic Details
Published inJournal of helminthology Vol. 68; no. 2; p. 143
Main Authors McHugh, T D, Jenkins, T, Greenwood, R, McLaren, D J
Format Journal Article
LanguageEnglish
Published England 01.06.1994
Subjects
Animals
Autoradiography
Brain - parasitology
Cohort Studies
Digestive System - parasitology
Female
Heart - parasitology
Liver - parasitology
Lung - parasitology
Rats
Rats, Wistar - parasitology
Rodent Diseases - parasitology
Skin - parasitology
Strongyloides ratti - physiology
Strongyloidiasis - parasitology
Strongyloidiasis - veterinary
Trachea - parasitology
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Summary:Compressed organ autoradiography has been utilized to study the migration of the homogonic strain of Strongyloides ratti from the site of skin penetration to the gut. This transit is characterized by rapid disappearance of parasites from the cutaneous site of infection, followed by vascular dispersal throughout all organs investigated. For the first time, parasite migration in both naive and previously sensitized hosts is compared; the principal stations of migration are the same in the two groups although there is a quantitative difference in accumulation of parasites with time in these stations. Parasite attrition occurs in both groups of animals; however, in naive rats it is not manifest until day 20-25 post challenge, whereas in sensitized rats immune elimination occurs as early as 48 h post challenge.
ISSN:0022-149X
DOI:10.1017/S0022149X00013675