Teuchamaedol A, a new neo-clerodane diterpenoid from the aerial parts of Teucrium chamaedrys

[Display omitted] •A new neoclerodane diterpenoid was isolated from Teucrium chamaedrys.•This is the first neoclerodane possessing a tetrahydrofuran moiety.•It might be a precursor of neoclerodanes with a O-containing ring at C-12. A new neo-clerodane diterpenoid, teuchamaedol A (1) was isolated fro...

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Published inTetrahedron letters Vol. 100; pp. 153890 - 153892
Main Authors Kurimoto, Shin-ichiro, Wakabayashi, Koji, Sasaki, Yu F., Nakamura, Takanori, Kubota, Takaaki
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 22.06.2022
Elsevier
Subjects
Chemistry
Chemistry, Organic
Diterpenoid
diterpenoids
Lamiaceae
moieties
neo-Clerodane
oxygen
Physical Sciences
Science & Technology
spectral analysis
tetrahydrofuran
Teucrium chamaedrys
Diterpenoid
Lamiaceae
Teucrium chamaedrys
neo-Clerodane
GERMANDER
CLERODANE DITERPENOIDS
HEPATITIS
PORTULACA-GRANDIFLORA
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Summary:[Display omitted] •A new neoclerodane diterpenoid was isolated from Teucrium chamaedrys.•This is the first neoclerodane possessing a tetrahydrofuran moiety.•It might be a precursor of neoclerodanes with a O-containing ring at C-12. A new neo-clerodane diterpenoid, teuchamaedol A (1) was isolated from the EtOAc-soluble materials of the aerial parts of Teucrium chamaedrys. The structure of 1 was elucidated on the basis of spectral data. The absolute configuration of 1 was determined by modified Mosher’s method. Teuchamaedol A (1) is the first neo-clerodane diterpenoid possessing a tetrahydrofuran moiety without additional oxygen function.
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ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153890