A facile synthesis of novel ferrocene grafted spiro-indenoquinoxaline pyrrolizidines via one-pot multicomponent [3+2] cycloaddition of azomethine ylides

A facile one-pot synthesis of novel ferrocene grafted spiro-indenoquinoxaline pyrrolizidines via multicomponent-[3+2]-cycloaddition of azomethine ylides is described. The methodology is very simple and applicable to a wide variety of ferrocene derived dipolarophiles. The structures of cycloadducts w...

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Bibliographic Details
Published inTetrahedron letters Vol. 53; no. 49; pp. 6676 - 6681
Main Authors Suresh Babu, A.R., Gavaskar, D., Raghunathan, R.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 05.12.2012
Elsevier
Subjects
1,2-Phenylenediammine
Azomethine ylide
Chemistry
Chemistry, Organic
Cycloaddition
Ferrocene
Physical Sciences
Pyrrolizidines
Science & Technology
Spiro-indenoquinoxaline
1,2-Phenylenediammine
Cycloaddition
Spiro-indenoquinoxaline
Ferrocene
Azomethine ylide
Pyrrolizidines
STRATEGY
IMINES
POTENTIAL 1,3-DIPOLES
DECARBOXYLATIVE ROUTE
X=Y-ZH SYSTEMS
1,3-DIPOLAR CYCLOADDITION
CONSTRUCTION
CONDENSATION
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Summary:A facile one-pot synthesis of novel ferrocene grafted spiro-indenoquinoxaline pyrrolizidines via multicomponent-[3+2]-cycloaddition of azomethine ylides is described. The methodology is very simple and applicable to a wide variety of ferrocene derived dipolarophiles. The structures of cycloadducts were confirmed by spectroscopic analysis. X-ray analysis of one of the analogs, adds conclusive support to the proposed structures.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.09.104