Organization of Human Phospholipid Transfer Protein Gene

We have determined the exon/intron organization of the human phospholipid transfer protein gene. The gene, which spans approximately 13.3 kilobases, is comprised of 16 exons. The organization of the phospholipid transfer protein gene strikingly resembles that encoding another plasma lipid transfer p...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 207; no. 2; pp. 552 - 558
Main Authors Tu, A.Y., Deeb, S.S., Iwasaki, L., Day, J.R., Albers, J.J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.02.1995
Subjects
Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Carrier Proteins - genetics
Codon
DNA Primers
Exons
Hominidae - genetics
Humans
Introns
Membrane Proteins - genetics
Molecular Sequence Data
Phospholipid Transfer Proteins
Phospholipids - metabolism
Polymerase Chain Reaction
Sequence Homology, Nucleic Acid
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Summary:We have determined the exon/intron organization of the human phospholipid transfer protein gene. The gene, which spans approximately 13.3 kilobases, is comprised of 16 exons. The organization of the phospholipid transfer protein gene strikingly resembles that encoding another plasma lipid transfer protein, the human cholesterol ester transfer protein. The exon-intron junctions in these two genes are highly conserved, with eight out of fifteen junctions interrupting the same codons, while the remaining junctions lie within 5 residues of each other. The similarity in gene structure and homology in coding sequences suggests that these two genes most likely evolved from a common ancestral gene.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1995.1223