Pd-catalyzed decarboxylative cross-coupling of perfluorobenzoic acids with simple arenes

Using a Pd/Ag bimetallic system, arylations of simple arenes with perfluorobenzoic acids have been achieved by decarboxylative C–H bond functionalization, providing the desired cross-coupling products in moderate to good yields. These straightforward protocols provide new and efficient methods for t...

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Bibliographic Details
Published inTetrahedron letters Vol. 54; no. 22; pp. 2833 - 2836
Main Authors Luo, Hai-Qing, Dong, Wen, Loh, Teck-Peng
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 29.05.2013
Elsevier
Subjects
Aromatic compounds
Bimetals
Bonding
Chemistry
Chemistry, Organic
Cross coupling
Crosscoupling
Decarboxylative
Fluorobiphenyl
Palladium
Pd-catalyzed
Physical Sciences
Scaffolds
Science & Technology
Simple arenes
Synthesis
Tetrahedrons
Crosscoupling
Simple arenes
Decarboxylative
Pd-catalyzed
Fluorobiphenyl
PALLADATION
PALLADIUM
DIRECT ARYLATION
MECHANISM
ARYL BROMIDES
OLEFINATION
BONDS
POTASSIUM POLYFLUOROBENZOATES
CARBOXYLIC-ACIDS
BENZOIC-ACIDS
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Summary:Using a Pd/Ag bimetallic system, arylations of simple arenes with perfluorobenzoic acids have been achieved by decarboxylative C–H bond functionalization, providing the desired cross-coupling products in moderate to good yields. These straightforward protocols provide new and efficient methods for the synthesis of fluorobiphenyl scaffolds under simple and mild conditions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.03.086