Serum protein binding of tolbutamide in patients treated with antiepileptic drugs

The possible development of a displacement interaction involving tolbutamide, in epileptic patients, has been explored by studying the serum protein binding of this drug in vitro in 199 samples of sera from patients treated with antiepileptic agents included in a programme of therapeutic drug monito...

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Bibliographic Details
Published inClinical pharmacokinetics Vol. 10; no. 5; p. 451
Main Authors Fernández, M C, Erill, S, Lucena, M I, Pita, E, Pérez-Alférez, N
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1985
Subjects
Adolescent
Adult
Anticonvulsants - adverse effects
Anticonvulsants - blood
Binding, Competitive
Blood Proteins - metabolism
Child
Clonazepam - pharmacology
Drug Interactions
Female
Humans
Male
Middle Aged
Phenobarbital - pharmacology
Phenytoin - pharmacology
Protein Binding
Tolbutamide - blood
Valproic Acid - pharmacology
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Summary:The possible development of a displacement interaction involving tolbutamide, in epileptic patients, has been explored by studying the serum protein binding of this drug in vitro in 199 samples of sera from patients treated with antiepileptic agents included in a programme of therapeutic drug monitoring. 82 of the samples were from patients receiving a single drug, 86 from patients treated with 2 drugs, and 31 from patients treated with 3 drugs. The free fraction of tolbutamide was higher in serum from patients treated with antiepileptic drugs than in serum from untreated 'normal' volunteers. The increase was more marked the greater the number of antiepileptic drugs administered. Valproate appeared to be the most powerful displacing agent.
ISSN:0312-5963
DOI:10.2165/00003088-198510050-00007