Loncastuximab Tesirine in the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

• Published in: International journal of molecular sciences Vol. 25; no. 14; p. 7580
• Main Authors: Juárez-Salcedo, Luis Miguel, Nimkar, Santosh, Corazón, Ana María, Dalia, Samir
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2024
• Subjects: Antibodies; Antibodies, Monoclonal, Humanized - therapeutic use; antibody–drug conjugate; Antigens; Antigens, CD19 - immunology; Antimitotic agents; Antineoplastic agents; B cells; Benzodiazepines; Care and treatment; Cell death; Chemotherapy; Cytotoxicity; Development and progression; diffuse large-B-cell lymphoma; Drug dosages; Enzymes; FDA approval; Humans; Immunoconjugates - pharmacology; Immunoconjugates - therapeutic use; immunotherapy; loncastuximab tesirine; Lymphoma; Lymphoma, Large B-Cell, Diffuse - drug therapy; Lymphoma, Large B-Cell, Diffuse - therapy; Lymphomas; Medical prognosis; Medical research; Monoclonal antibodies; Neoplasm Recurrence, Local - drug therapy; refractory/relapse; Response rates; Stem cells; T cells; Toxicity; Transplantation; Transplants & implants; Viral antibodies; loncastuximab tesirine; refractory/relapse; antibody–drug conjugate; diffuse large-B-cell lymphoma; immunotherapy
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25147580

Currently, a significant percentage of patients with DLBCL are refractory or relapse after a first line of immunochemotherapy. Second relapses after autologous stem cell transplantation or chimeric antigen receptor T-cell therapies present few treatment options and do not yield good results. New molecules have entered the immunotherapy arsenal. Loncastuximab tesirine comprises a humanized anti-CD19 monoclonal conjugated antibody, which consists of an anti-CD19 antibody and cytotoxic alkylating agent, SG3199. Several studies have proven its efficacy in the treatment of refractory cases of DLBCL with a good safety profile, with the main adverse effects being neutropenia, thrombopenia, and liver enzyme involvement. In this review, we explain the mechanism of action of this molecule, the clinical data that have led to its acceptance by the FDA, and the new therapeutic options that are proposed in association with this drug.