Multi-component, 1,3-dipolar cycloaddition reactions for the chemo-, regio- and stereoselective synthesis of novel hybrid spiroheterocycles in ionic liquid

A library of novel 1-methyl-4-arylpyrrolo-(spiro[2.2′]indan-1′,3′-dione)-spiro[3.3″]-1″-methyl/benzyl-5″-(arylmethylidene)piperidin-4″-ones and 1-methyl-4-arylpyrrolo-(spiro[2.11′]-11H-indeno[1,2-b]quinoxaline)-spiro[3.3″]-1″-methyl/benzyl-5″-(arylmethylidene)piperidin-4″-ones have been synthesized...

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Bibliographic Details
Published inTetrahedron letters Vol. 53; no. 40; pp. 5367 - 5371
Main Authors Michael Rajesh, Stephen, Bala, Balasubramainan Devi, Perumal, Subbu
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 03.10.2012
Elsevier
Subjects
1,3-Dipolar cycloaddition
Bromides
Chemistry
Chemistry, Organic
Cycloaddition
Ionic liquid
Ionic liquids
Libraries
Multi-component reactions
Physical Sciences
Quinoxalines
Science & Technology
Spiroheterocycles
Synthesis (chemistry)
Tetrahedrons
1,3-Dipolar cycloaddition
Quinoxalines
Multi-component reactions
Spiroheterocycles
Ionic liquid
DOMINO REACTIONS
CONVERSION
ONE-POT
AZOMETHINE YLIDES
5-HT3 RECEPTOR AGONISTS
NINHYDRIN
DIASTEREOSELECTIVE SYNTHESIS
INHIBITORS
FACILE
DERIVATIVES
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Summary:A library of novel 1-methyl-4-arylpyrrolo-(spiro[2.2′]indan-1′,3′-dione)-spiro[3.3″]-1″-methyl/benzyl-5″-(arylmethylidene)piperidin-4″-ones and 1-methyl-4-arylpyrrolo-(spiro[2.11′]-11H-indeno[1,2-b]quinoxaline)-spiro[3.3″]-1″-methyl/benzyl-5″-(arylmethylidene)piperidin-4″-ones have been synthesized via 1,3-dipolar azomethine ylide cycloaddition in the ionic liquid, 1-butyl-3-methylimidazolium bromide ([BMIm]Br), in excellent yields.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.07.078