Fabrication of nanofibrous tubular scaffolds for bone tissue engineering

• Published in: Materials letters Vol. 182; pp. 289 - 293
• Main Authors: Chen, Shunyu, He, Zhihang, Xu, Guojie, Xiao, Xiufeng
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2016
• Subjects: Biomaterials; Bone tissue engineering; Bones; Centrifugation; Electric potential; Nanofibrous tubular scaffolds; Nanostructure; Phase separation; Polymer; Scaffolds; Sucrose; Thermally induced phase separation; Tissue engineering; Voltage; Thermally induced phase separation; Polymer; Bone tissue engineering; Nanofibrous tubular scaffolds; Centrifugation; Biomaterials
• ISSN: 0167-577X; 1873-4979
• DOI: 10.1016/j.matlet.2016.07.015

Nanofibrous tubular poly(L-lactic acid) (PLLA) scaffolds were fabricated by centrifugation combined with thermally induced phase separation technique using PLLA/1,4-dioxane/water ternary system, at input voltage of 4.00V and phase separation temperature of −15°C. Addition of sucrose led to the generation of porous scaffolds with interconnected pores. Input voltage was the crucial factor to generate nanofibrous tubular scaffold that mimicked the structural features of the biological systems. The surface of nanofibrous tubular scaffold provided a good environment for attachment and proliferation of MC3T3-E1 subclone 14 cells, exhibiting significant potential for bone tissue regeneration. •Nanofibrous porous tubular PLLA scaffolds were prepared by TIPS with centrifugation.•Scaffolds provide an advantageous environment for the cells adhesion and viability.•4.00V was the most appropriate voltage for fabricating perforated tubular scaffolds.