Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice

Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin （C-PC）, a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect agai...

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Published inChinese journal of oceanology and limnology Vol. 34; no. 2; pp. 399 - 404
Main Author 夏冬 刘冰 栾希英 孙军燕 刘娜娜 秦松 杜振宁
Format Journal Article
LanguageEnglish
Published Heidelberg Science Press 01.03.2016
Springer Nature B.V
Subjects
Alanine
Alanine transaminase
alcohol drinking
Alcohols
Algae
Arthrospira platensis
Aspartate aminotransferase
aspartate transaminase
blood serum
Chemical damage
Cholesterol
Chromophores
Cloud cover
Earth and Environmental Science
Earth Sciences
eS4 Coastal Biotechnology
Ethanol
Hepatocytes
Inflammation
Injury prevention
Lipoproteins
Liver
Liver diseases
Low density lipoprotein
malondialdehyde
mice
Necrosis
Oceanography
Phycocyanin
Phycocyanobilin
Phytochemicals
protective effect
Rodents
Serum
Spirulina platensis
Superoxide dismutase
Transaminases
triacylglycerols
Triglycerides
Wounds
丙氨酸氨基转移酶
乙醇
保护作用
化学诱导
小鼠
急性肝损伤
藻蓝蛋白
超氧化物歧化酶
acute ethanol liver injury
protective effect
C-phycocyanin
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ISSN0254-4059
2096-5508
1993-5005
2523-3521
DOI10.1007/s00343-015-4312-6

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Summary:Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin （C-PC）, a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, triglyceride （TG）, total cholesterol （CHOL）, low-density lipoprotein （LDL）, liver homogenate malondialdehyde （MDA）, superoxide dismutase （SOD） content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.
Bibliography:37-1150/P
Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin （C-PC）, a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, triglyceride （TG）, total cholesterol （CHOL）, low-density lipoprotein （LDL）, liver homogenate malondialdehyde （MDA）, superoxide dismutase （SOD） content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.
C-phycocyanin; acute ethanol liver injury; protective effect
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ISSN:0254-4059
2096-5508
1993-5005
2523-3521
DOI:10.1007/s00343-015-4312-6