Modulating the tumor-associated macrophage landscape

Targeting the post-translational modification enzyme QPCTL prevents the protection of CCL2 and CCL7 from N-terminal degradation, inactivates their chemotactic function and limits the recruitment of pro-tumoral macrophages.

Saved in:
Bibliographic Details
Published inNature immunology Vol. 23; no. 4; pp. 481 - 482
Main Authors Boissonnas, Alexandre, Combadière, Christophe
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.04.2022
Nature Publishing Group
Subjects
631/250/2504/342
631/250/580
631/250/98
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cancer
Chemokines
Enzymes
Immunology
Infectious Diseases
Life Sciences
Macrophage Activation
Macrophages
Medical prognosis
Monocyte chemoattractant protein 1
News & Views
news-and-views
Post-translation
Tumor Microenvironment
Tumor-Associated Macrophages
Tumors
Online AccessGet full text

Cover

More Information
Summary:Targeting the post-translational modification enzyme QPCTL prevents the protection of CCL2 and CCL7 from N-terminal degradation, inactivates their chemotactic function and limits the recruitment of pro-tumoral macrophages.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Commentary-3
content type line 23
ISSN:1529-2908
1529-2916
1529-2916
DOI:10.1038/s41590-022-01159-5