Variable number of tandem repeats in zygosity diagnosis in twins

The use of DNA restriction fragment length polymorphisms (RFLP) to analyze variable number of tandem repeat (VNTR) sequences dispersed in the human genome, has become a powerful tool for the study of population genetics due to the very substantial polymorphism involved. Because the markers usually e...

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Bibliographic Details
Published inActa geneticae medicae et gemellologiae Vol. 39; no. 4; p. 473
Main Authors Costanzi Porrini, S, Sciarra, A, Sulli, N, Piane, M, Gualtieri, R, Del Porto, G
Format Journal Article
LanguageEnglish
Published Italy 1990
Subjects
Base Sequence
Blood Group Antigens - genetics
Genetic Markers
HLA Antigens - genetics
Humans
Molecular Sequence Data
Oligonucleotide Probes
Polymorphism, Restriction Fragment Length
Repetitive Sequences, Nucleic Acid
Twins - genetics
Twins, Dizygotic
Twins, Monozygotic
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Summary:The use of DNA restriction fragment length polymorphisms (RFLP) to analyze variable number of tandem repeat (VNTR) sequences dispersed in the human genome, has become a powerful tool for the study of population genetics due to the very substantial polymorphism involved. Because the markers usually employed for twin zygosity determination (such as sex combination, placentation, HLA typing, blood group antigens, etc) may not be uniformly informative, we propose the use of synthetic olygonucleotides, representing VNTR "core" sequences, for the determination of zygosity in twins.
ISSN:0001-5660
DOI:10.1017/S000156600000369X