Orthostatic effect of imipramine and doxepin in depressed geriatric outpatients

Blood pressure measurements were collected from 36 depressed geriatric outpatients (ages 55 to 81 years) enrolled in a double-blind, placebo-controlled study of the efficacy of doxepin and imipramine. Mean systolic postural changes were 25.9 mm Hg for imipramine, significantly higher than the 10.5 m...

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Published inJournal of clinical psychopharmacology Vol. 5; no. 2; p. 102
Main Authors Neshkes, R E, Gerner, R, Jarvik, L F, Mintz, J, Joseph, J, Linde, S, Aldrich, J, Conolly, M E, Rosen, R, Hill, M
Format Journal Article
LanguageEnglish
Published United States 01.04.1985
Subjects
Age Factors
Aged
Depressive Disorder - drug therapy
Double-Blind Method
Doxepin - adverse effects
Female
Humans
Hypotension, Orthostatic - chemically induced
Imipramine - adverse effects
Male
Middle Aged
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Summary:Blood pressure measurements were collected from 36 depressed geriatric outpatients (ages 55 to 81 years) enrolled in a double-blind, placebo-controlled study of the efficacy of doxepin and imipramine. Mean systolic postural changes were 25.9 mm Hg for imipramine, significantly higher than the 10.5 mm Hg for doxepin, and 12.4 mm Hg for placebo. The orthostatic drop in the imipramine group was only weakly related to dose and did not correlate with amount of pretreatment orthostatic hypotension or with duration of treatment. The increased orthostatic hypotension occurred early in treatment and at low doses of imipramine. Accordingly, caution is advised in the use of imipramine for the elderly.
ISSN:0271-0749
DOI:10.1097/00004714-198504000-00009