A CYTOTOXIC PYRANONAPHTHOQUINONE FROM CULTURED LICHEN MYCOBIONTS OF HAEMATOMMA sp

Spore-derived mycobionts of the lichen Haematomma sp. were cultivated on malt-yeast extract medium supplemented with 10% sucrose to produce a new pyranonaphthoquinone, 4, as well as two known compounds (-)-usnic acid (2) and 5-deoxy-7-methylbostrycoidin (3). The structure of 4 was determined by spec...

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Published inHeterocycles Vol. 94; no. 9; pp. 1728 - 1735
Main Authors Takenaka, Yukiko, Mizushina, Yoshiyuki, Hamada, Nobuo, Tanahashi, Takao
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 2017
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
METABOLITES
GRAPHIS-SCRIPTA
DERIVATIVES
DNA
BETA
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Abstract Spore-derived mycobionts of the lichen Haematomma sp. were cultivated on malt-yeast extract medium supplemented with 10% sucrose to produce a new pyranonaphthoquinone, 4, as well as two known compounds (-)-usnic acid (2) and 5-deoxy-7-methylbostrycoidin (3). The structure of 4 was determined by spectroscopic methods. The inhibitory activities of 3, 4, and 6-8 against mammalian DNA polymerases (pols) and cytotoxic effects against a HeLa human cervical cancer cell line were also evaluated. Compound 4 showed the strongest mammalian pol inhibitory activity and cytotoxicity (ID50 = 6.7 mu M) among the tested compounds.
AbstractList Spore-derived mycobionts of the lichen Haematomma sp. were cultivated on malt-yeast extract medium supplemented with 10% sucrose to produce a new pyranonaphthoquinone, 4, as well as two known compounds (-)-usnic acid (2) and 5-deoxy-7-methylbostrycoidin (3). The structure of 4 was determined by spectroscopic methods. The inhibitory activities of 3, 4, and 6-8 against mammalian DNA polymerases (pols) and cytotoxic effects against a HeLa human cervical cancer cell line were also evaluated. Compound 4 showed the strongest mammalian pol inhibitory activity and cytotoxicity (ID50 = 6.7 mu M) among the tested compounds.
Author Mizushina, Yoshiyuki
Hamada, Nobuo
Tanahashi, Takao
Takenaka, Yukiko
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  organization: Kobe Pharmaceut Univ, Higashinada Ku, 4-19-1 Motoyamakita Machi, Kobe, Hyogo 6588558, Japan
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Cites_doi 10.1021/np800570w
10.3987/COM-13-12768
10.1007/s11101-009-9149-1
10.1021/np500143k
10.1038/nrg2345
10.1016/j.phytochem.2012.01.009
10.1111/j.1356-9597.2004.00747.x
10.1039/b606983p
10.1007/s11101-010-9189-6
10.1271/bbb.90121
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Snippet Spore-derived mycobionts of the lichen Haematomma sp. were cultivated on malt-yeast extract medium supplemented with 10% sucrose to produce a new...
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Chemistry, Organic
Physical Sciences
Science & Technology
Title A CYTOTOXIC PYRANONAPHTHOQUINONE FROM CULTURED LICHEN MYCOBIONTS OF HAEMATOMMA sp
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