A CYTOTOXIC PYRANONAPHTHOQUINONE FROM CULTURED LICHEN MYCOBIONTS OF HAEMATOMMA sp

Spore-derived mycobionts of the lichen Haematomma sp. were cultivated on malt-yeast extract medium supplemented with 10% sucrose to produce a new pyranonaphthoquinone, 4, as well as two known compounds (-)-usnic acid (2) and 5-deoxy-7-methylbostrycoidin (3). The structure of 4 was determined by spec...

Full description

Saved in:
Bibliographic Details
Published inHeterocycles Vol. 94; no. 9; pp. 1728 - 1735
Main Authors Takenaka, Yukiko, Mizushina, Yoshiyuki, Hamada, Nobuo, Tanahashi, Takao
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 2017
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
METABOLITES
GRAPHIS-SCRIPTA
DERIVATIVES
DNA
BETA
Online AccessGet more information

Cover

More Information
Summary:Spore-derived mycobionts of the lichen Haematomma sp. were cultivated on malt-yeast extract medium supplemented with 10% sucrose to produce a new pyranonaphthoquinone, 4, as well as two known compounds (-)-usnic acid (2) and 5-deoxy-7-methylbostrycoidin (3). The structure of 4 was determined by spectroscopic methods. The inhibitory activities of 3, 4, and 6-8 against mammalian DNA polymerases (pols) and cytotoxic effects against a HeLa human cervical cancer cell line were also evaluated. Compound 4 showed the strongest mammalian pol inhibitory activity and cytotoxicity (ID50 = 6.7 mu M) among the tested compounds.
Bibliography:KAKEN
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-17-13704