Experimental models in primates for reconstructive surgery utilizing tissue transplants

Two experimental models for tissue transplantation between unrelated individuals of a primate species have been designed to study survival and reinnervation. The first is a neurovascular free flap consisting of the entire soft tissue coverage of the index finger. The second is an entire hand transpl...

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Bibliographic Details
Published inAnnals of plastic surgery Vol. 13; no. 5; p. 423
Main Authors Egerszegi, E P, Samulack, D D, Daniel, R K
Format Journal Article
LanguageEnglish
Published United States 01.11.1984
Subjects
Animals
Cyclosporins - therapeutic use
Hand - innervation
Hand - surgery
Hand Transplantation
History, 19th Century
History, 20th Century
Immunosuppression
Intraoperative Care
Papio
Postoperative Care
Skin Transplantation
Surgical Flaps
Transplantation - history
Transplantation Immunology
Transplantation, Heterologous
Transplantation, Homologous
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Summary:Two experimental models for tissue transplantation between unrelated individuals of a primate species have been designed to study survival and reinnervation. The first is a neurovascular free flap consisting of the entire soft tissue coverage of the index finger. The second is an entire hand transplant through the distal forearm. Ongoing studies show that cyclosporin A at high doses, in combination with a tapering regimen of steroids to a low maintenance level, permits prolonged survival of both transplant models. Careful biochemical, hematological, and cyclosporin A serum trough level monitoring permits use of this drug a very high dosages in primates. Continuing experiments should yield detailed neurophysiological data on the reinnervation of these transplants over the next 6 to 18 months.
ISSN:0148-7043
DOI:10.1097/00000637-198411000-00010