Human papilloma virus (HPV) infection leads to the development of head and neck lesions but offers better prognosis in malignant Indian patients

• Published in: Medical microbiology and immunology Vol. 206; no. 3; pp. 267 - 276
• Main Authors: Sarkar, Shreya, Alam, Neyaz, Chakraborty, Jayanta, Biswas, Jaydip, Mandal, Syam Sundar, Roychoudhury, Susanta, Panda, Chinmay Kumar
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2017; Springer Nature B.V
• Subjects: Adult; Aged; Biomedical and Life Sciences; Biomedicine; Female; Head and Neck Neoplasms - etiology; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Humans; Immunology; India - epidemiology; Male; Medical Microbiology; Middle Aged; Neoplasm Staging; Original Investigation; Papillomaviridae - classification; Papillomaviridae - isolation & purification; Papillomavirus Infections - complications; Papillomavirus Infections - epidemiology; Papillomavirus Infections - virology; Prevalence; Prognosis; Risk Factors; Survival Analysis; Virology; Human papilloma virus; Head and neck squamous cell carcinoma; Prognostic marker
• ISSN: 0300-8584; 1432-1831
• DOI: 10.1007/s00430-017-0502-5

Head and neck cancers constitute a multifactorial global disease burden and are associated with human papilloma virus (HPV) as a possible risk factor. The aim of the study is to understand the relationship between HPV and the development of head and neck lesions in Indian patients. To this end, frequency of HPV was assessed in relation to different demographic and etiological features and correlated with patient survival. The prevalence of HPV significantly increased from mild dysplastic lesions (43.6%) to head and neck squamous cell carcinoma (HNSCC) stage IV (68.5%) with HPV 16 being pre-dominant in both dysplasia (43.8%) and HNSCC (61.5%). Similar trend was observed in increasing grades of the tumour. In invasive lesions, patients aged below the median age of onset showed significantly higher occurrence of HPV than those above it. Patients harbouring HPV showed a significantly better survival irrespective of age of onset. Likewise, better survival was observed in tobacco habit negative/HPV-positive patients, and as reflected in both univariate and multivariate analysis. Majority of the HPV 16-positive samples showed moderate/high nuclear expression of HPV E6 and E7 proteins in tumours and respective basal layer of adjacent normal tissues. Thus, our data indicate that frequent HPV infection, along with tobacco habit, is a pre-requisite factor for the development of HNSCC of Indian patients but offers a better survival even during tobacco usage, implicating its diagnostic and prognostic importance.