Applications of Hantzsch Esters in Organocatalytic Enantioselective Synthesis

Hantzsch esters (1,4-dihydropyridine dicarboxylates) have become, in this century, very versatile reagents for enantioselective organic transformations. They can act as hydride transfer agents to reduce, regioselectively, a variety of multiple bonds, e.g., C=C and C=N, under mild reaction conditions...

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Bibliographic Details
Published inCatalysts Vol. 13; no. 2; p. 419
Main Authors Faisca Phillips, Ana Maria, Pombeiro, Armando J. L.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.02.2023
Subjects
1,4-dihydropyridine dicarboxylates
Acids
Alcohol
Bonding agents
Catalysts
Chemical reactions
Chemical tests and reagents
chiral phosphoric acid
Enantiomers
enantioselective catalysis
Esters
Hydrogen
Hydrogenation
Literature reviews
Metals
Olefins
Photocatalysis
photoredox catalysis
Reagents
transfer hydrogenation
transfer-alkylation
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Summary:Hantzsch esters (1,4-dihydropyridine dicarboxylates) have become, in this century, very versatile reagents for enantioselective organic transformations. They can act as hydride transfer agents to reduce, regioselectively, a variety of multiple bonds, e.g., C=C and C=N, under mild reaction conditions. They are excellent reagents for the dearomatization of heteroaromatic substances, and participate readily in cascade processes. In the last few years, they have also become useful reagents for photoredox reactions. They can participate as sacrificial electron and hydrogen donors and when 4-alkyl or 4-acyl-substituted, they can act as alkyl or acyl radical transfer agents. These last reactions may take place in the presence or absence of a photocatalyst. This review surveys the literature published in this area in the last five years.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal13020419