High dose rate vaginal brachytherapy in early stage endometrial carcinoma: preliminary analysis

From 1987 to 1993, 69 women diagnosed with FIGO stages I and II carcinoma of the endometrium underwent postoperative adjuvant irradiation (RT) under protocol with high dose rate (HDR) afterloading vaginal apex brachytherapy. All patients initially underwent total abdominal hysterectomy and bilateral...

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Bibliographic Details
Published inAmerican journal of clinical oncology Vol. 20; no. 3; p. 254
Main Authors Hong, J J, Yacoub, S F, Blevins, J C, Kuban, D A, el-Mahdi, A M
Format Journal Article
LanguageEnglish
Published United States 01.06.1997
Subjects
Adenocarcinoma - radiotherapy
Adult
Aged
Brachytherapy - methods
Disease-Free Survival
Endometrial Neoplasms - radiotherapy
Female
Follow-Up Studies
Humans
Hysterectomy
Middle Aged
Neoplasm Staging
Ovariectomy
Proportional Hazards Models
Radiotherapy Dosage
Radiotherapy, Adjuvant
Vagina
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Summary:From 1987 to 1993, 69 women diagnosed with FIGO stages I and II carcinoma of the endometrium underwent postoperative adjuvant irradiation (RT) under protocol with high dose rate (HDR) afterloading vaginal apex brachytherapy. All patients initially underwent total abdominal hysterectomy and bilateral salpingo-oopherectomy. Forty-four women received HDR brachytherapy alone and 25 received external beam RT as well as HDR brachytherapy. The median follow-up was 45 months. The 5-year disease-free survival was 92% and the overall survival rate was 79%. Multivariate Cox regression analysis revealed that grade, age, and stage were significant predictors of survival. The overall acute and late side effects were minimal. It appears that HDR vaginal brachytherapy is prevention of vaginal recurrence in endometrial carcinoma and should be considered an effective treatment option.
ISSN:0277-3732
DOI:10.1097/00000421-199706000-00009