A simple, convenient one-pot synthesis of [1,2,4]triazolo/benzimidazolo quinazolinone derivatives by using molecular iodine

A wide variety of quinazolinone derivatives have been synthesized by condensation of 3-amino-1,2,4-triazole and 2-aminobenzimidazole as amine sources, with aromatic aldehydes and dimedone in the presence of 10mol% of molecular iodine in acetonitrile under reflux conditions through one-pot reactions....

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Published inTetrahedron letters Vol. 54; no. 20; pp. 2480 - 2483
Main Authors Puligoundla, Ravinder Goud, Karnakanti, Shuklachary, Bantu, Rajashaker, Nagaiah, Kommu, Kondra, Sudhakar Babu, Nagarapu, Lingaiah
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.05.2013
Elsevier
Subjects
2-Aminobenzimidazole
3-Amino-1,2,4-triazole
Acceptability
Acetonitrile
Chemistry
Chemistry, Organic
Chromatography
Derivatives
Iodine
Molecular iodine
Physical Sciences
Quinazolinones
Science & Technology
Synthesis (chemistry)
Tetrahedrons
2-Aminobenzimidazole
3-Amino-1,2,4-triazole
Molecular iodine
MULTICOMPONENT REACTIONS
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Summary:A wide variety of quinazolinone derivatives have been synthesized by condensation of 3-amino-1,2,4-triazole and 2-aminobenzimidazole as amine sources, with aromatic aldehydes and dimedone in the presence of 10mol% of molecular iodine in acetonitrile under reflux conditions through one-pot reactions. Environmental acceptability, low cost, no need of chromatographic separation, and high yields are the important features of this protocol.
Bibliography:ObjectType-Article-1
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ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.02.099