Penicisochromans from the endophytic fungus Penicillium sp. BCC18034

• Published in: Phytochemistry letters Vol. 10; pp. 13 - 18
• Main Authors: Bunbamrung, Nantiya, Intaraudom, Chakapong, Boonyuen, Nattawut, Rachtawee, Pranee, Laksanacharoen, Pattiyaa, Pittayakhajonwut, Pattama
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2014
• Subjects: Antimalarial; Cytotoxicity; Endophyte; Penicillium; Penicisochromans; Plasmodium falciparum; Antimalarial; Endophyte; Cytotoxicity; Penicisochromans; Penicillium
• ISSN: 1874-3900; 1876-7486
• DOI: 10.1016/j.phytol.2014.06.018

New penicisochroman derivatives have been isolated from the endophytic fungus Penicillium sp. BCC18034. The isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum, K-1 strain and for cytotoxicity against cancerous and non-cancerous cells. •Eight new compounds, penicisochromans F–L and penicibenzoxepinol, have been isolated from the endophytic fungus Penicillium sp. BCC18034.•The isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum, K-1 strain and for cytotoxicity against MCF-7, KB, NCI-H187, and Vero cells.•Two known compounds, chlamydocin and brefeldin A, showed strong antimalarial activity. Eight new substances including penicisochromans F–L, and penicibenzoxepinol along with seven known substances were isolated from the endophytic Penicillium sp. BCC18034. Their chemical structures were determined based on 1D and 2D NMR spectroscopic data and HR-ESI-MS analyses. Biological activities against Plasmodium falciparum, MCF-7, NCI-H187, and Vero cells of the isolated compounds were also reported.