Penicisochromans from the endophytic fungus Penicillium sp. BCC18034
New penicisochroman derivatives have been isolated from the endophytic fungus Penicillium sp. BCC18034. The isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum, K-1 strain and for cytotoxicity against cancerous and non-cancerous cells. •Eight new compounds, peni...
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Published in | Phytochemistry letters Vol. 10; pp. 13 - 18 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.12.2014
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Subjects | |
Online Access | Get full text |
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Summary: | New penicisochroman derivatives have been isolated from the endophytic fungus Penicillium sp. BCC18034. The isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum, K-1 strain and for cytotoxicity against cancerous and non-cancerous cells.
•Eight new compounds, penicisochromans F–L and penicibenzoxepinol, have been isolated from the endophytic fungus Penicillium sp. BCC18034.•The isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum, K-1 strain and for cytotoxicity against MCF-7, KB, NCI-H187, and Vero cells.•Two known compounds, chlamydocin and brefeldin A, showed strong antimalarial activity.
Eight new substances including penicisochromans F–L, and penicibenzoxepinol along with seven known substances were isolated from the endophytic Penicillium sp. BCC18034. Their chemical structures were determined based on 1D and 2D NMR spectroscopic data and HR-ESI-MS analyses. Biological activities against Plasmodium falciparum, MCF-7, NCI-H187, and Vero cells of the isolated compounds were also reported. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1874-3900 1876-7486 |
DOI: | 10.1016/j.phytol.2014.06.018 |