Studies on Human Porin XVI: Polyamines Reduce the Voltage Dependence of Human VDAC in Planar Lipid Bilayers—Spermine and Spermidine Inducing Asymmetric Voltage Gating on the Channel

We present the first data on the effects of polyamines on human VDAC. Purified VDAC in lipid bilayers shows lowered voltage dependence whenever putrescine, cadaverine, spermine, spermidine, or the histamine releaser Compound 48/80, respectively, are applied. Only spermine and spermidine induce an as...

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Published inMolecular genetics and metabolism Vol. 63; no. 3; pp. 239 - 242
Main Authors Horn, Andrea, Reymann, Susanne, Thinnes, Friedrich P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.1998
Subjects
channel regulation
compound 48/80
Humans
Ion Channel Gating - drug effects
Ion Channels - drug effects
Ion Channels - physiology
Lipid Bilayers
Membrane Potentials
Membrane Proteins - physiology
p-Methoxy-N-methylphenethylamine - pharmacology
polyamines
Polyamines - pharmacology
porin
Porins
Spermidine - pharmacology
Spermine - pharmacology
VDAC
Voltage-Dependent Anion Channels
VDAC
channel regulation
compound 48/80
polyamines
porin
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Summary:We present the first data on the effects of polyamines on human VDAC. Purified VDAC in lipid bilayers shows lowered voltage dependence whenever putrescine, cadaverine, spermine, spermidine, or the histamine releaser Compound 48/80, respectively, are applied. Only spermine and spermidine induce an asymmetric reaction on the channel. However, we state a groupwise different reaction of polyamines, which are organic polycations, on human porin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1096-7192
1096-7206
DOI:10.1006/mgme.1997.2671