Mesoporous silica coatings for cephalosporin active release at the bone-implant interface

• Published in: Applied surface science Vol. 374; pp. 165 - 171
• Main Authors: Rădulescu, Dragoş, Voicu, Georgeta, Oprea, Alexandra Elena, Andronescu, Ecaterina, Grumezescu, Valentina, Holban, Alina Maria, Vasile, Bogdan Stefan, Surdu, Adrian Vasile, Grumezescu, Alexandru Mihai, Socol, Gabriel, Mogoantă, Laurenţiu, Mogoşanu, George Dan, Balaure, Paul Cătălin, Rădulescu, Radu, Chifiriuc, Mariana Carmen
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 30.06.2016
• Subjects: Antimicrobial coatings; Biocompatibility; Biodistribution; Bones; Coatings; Drug controlled release; Drug delivery systems; Escherichia coli; Granular materials; Silicon dioxide; Surface chemistry; Transmission electron microscopy; Zinforo; Antimicrobial coatings; Biodistribution; Escherichia coli; Drug controlled release; Zinforo
• ISSN: 0169-4332; 1873-5584
• DOI: 10.1016/j.apsusc.2015.10.183

•Silica/Zinforo thin coatings by matrix assisted pulsed laser evaporation.•Anti-adherent coating on medical surfaces against E. coli.•Thin coatings show a great biocompatibility in vitro and in vivo. In this study, we investigated the potential of MAPLE-deposited coatings mesoporous silica nanoparticles (MSNs) to release Zinforo (ceftarolinum fosmil) in biologically active form. The MSNs were prepared by using a classic procedure with cetyltrimethylammonium bromide as sacrificial template and tetraethylorthosilicate as the monomer. The Brunauer–Emmett–Teller (BET) and transmission electron microscopy (TEM) analyses revealed network-forming granules with diameters under 100nm and an average pore diameter of 2.33nm. The deposited films were characterized by SEM, TEM, XRD and IR. Microbiological analyses performed on ceftaroline-loaded films demonstrated that the antibiotic was released in an active form, decreasing the microbial adherence rate and colonization of the surface. Moreover, the in vitro and in vivo assays proved the excellent biodistribution and biocompatibility of the prepared systems. Our results suggest that the obtained bioactive coatings possess a significant potential for the design of drug delivery systems and antibacterial medical-use surfaces, with great applications in bone implantology.