Serum Trans-Fatty Acids Are Associated with Risk of Prostate Cancer in β-Carotene and Retinol Efficacy Trial
Biomarkers of trans -fatty acid consumption have been associated with increased risks of breast and colon cancer, although no studies have examined their associations with prostate cancer risk. Using data from the β-Carotene and Retinol Efficacy Trial, this nested case-control study examined the rel...
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Published in | Cancer epidemiology, biomarkers & prevention Vol. 14; no. 4; pp. 988 - 992 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for Cancer Research
01.04.2005
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Subjects | |
Online Access | Get full text |
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Summary: | Biomarkers of trans -fatty acid consumption have been associated with increased risks of breast and colon cancer, although no studies have examined
their associations with prostate cancer risk. Using data from the β-Carotene and Retinol Efficacy Trial, this nested case-control
study examined the relationships between serum phospholipid trans -fatty acids and prostate cancer incidence in 272 case and 426 control men. Trans -fatty acids were measured using organic extraction followed by separations with TLC and gas chromatography. Adjusted odds
ratios for risk of prostate cancer with increasing levels of trans -fatty acids were calculated using logistic regression. There were consistent trends for increasing prostate cancer risk with
higher levels of C18 but not C16 trans -fatty acids, although only trends for Δ11 t 18:1 trans -vaccenic and Δ9 c, 12 t 18:2 fatty acids reached statistical significance. Odds ratios (95% confidence interval) contrasting low versus high quartiles
for these fatty acids were 1.69 (1.03-2.77) and 1.79 (1.02-3.15), respectively. There were no consistent differences in associations
between low-grade and high-grade cancer among the subset of 209 cases with information on tumor grade. Additional studies
are needed to confirm these findings and better control for factors, such as use of prostate-specific antigen screening, which
may confound this association. |
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ISSN: | 1055-9965 1538-7755 |
DOI: | 10.1158/1055-9965.EPI-04-0517 |