Clinically significant danazol-carbamazepine interaction

• Published in: Therapeutic drug monitoring Vol. 9; no. 1; p. 24
• Main Authors: Zielinski, J J, Lichten, E M, Haidukewych, D
• Format: Journal Article
• Language: English
• Published: United States 1987
• Subjects: Adult; Carbamazepine - adverse effects; Carbamazepine - blood; Carbamazepine - therapeutic use; Danazol - adverse effects; Danazol - therapeutic use; Drug Interactions; Epilepsy - drug therapy; Female; Fibrocystic Breast Disease - drug therapy; Humans; Kinetics; Pregnadienes - adverse effects; Valproic Acid - blood

In six patients with epilepsy and fibrocystic breast disease the concentration in serum of antiepileptic drugs was obtained before, during, and after danazol therapy. Carbamazepine serum levels increased almost twofold in the presence of danazol. Thus, interaction between carbamazepine and danazol p...