Clinically significant danazol-carbamazepine interaction

In six patients with epilepsy and fibrocystic breast disease the concentration in serum of antiepileptic drugs was obtained before, during, and after danazol therapy. Carbamazepine serum levels increased almost twofold in the presence of danazol. Thus, interaction between carbamazepine and danazol p...

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Bibliographic Details
Published inTherapeutic drug monitoring Vol. 9; no. 1; p. 24
Main Authors Zielinski, J J, Lichten, E M, Haidukewych, D
Format Journal Article
LanguageEnglish
Published United States 1987
Subjects
Adult
Carbamazepine - adverse effects
Carbamazepine - blood
Carbamazepine - therapeutic use
Danazol - adverse effects
Danazol - therapeutic use
Drug Interactions
Epilepsy - drug therapy
Female
Fibrocystic Breast Disease - drug therapy
Humans
Kinetics
Pregnadienes - adverse effects
Valproic Acid - blood
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Summary:In six patients with epilepsy and fibrocystic breast disease the concentration in serum of antiepileptic drugs was obtained before, during, and after danazol therapy. Carbamazepine serum levels increased almost twofold in the presence of danazol. Thus, interaction between carbamazepine and danazol producing acute carbamazepine toxicity is clinically significant. If these drugs are administered concurrently, an awareness of the potential for this drug-drug interaction along with monitoring of carbamazepine levels is required for optimal patient care.
ISSN:0163-4356
DOI:10.1097/00007691-198703000-00005