Precocious Puberty: An Endocrine Manifestation in Congenital Toxoplasmosis

We reviewed retrospectively seven children with congenital toxoplasmosis and precocious puberty. All seven showed very high levels of LH (25.2-155.0 IU/ml) and FSH (7.1-38.2) upon stimulation with GnRH. Three of them showed low GH response to an insulin tolerance test. All the children had severe me...

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Published inJournal of Pediatric Endocrinology and Metabolism Vol. 15; no. 9; pp. 1487 - 1490
Main Authors Setian, N., Andrade, R.S.F., Kuperman, H., Della Manna, T., Dichtchekenian, V., Damiani, D.
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 01.11.2002
Subjects
Child
Child, Preschool
Female
Humans
Infant
Luteinizing Hormone - blood
Male
Menarche
Puberty, Precocious - etiology
Retrospective Studies
Toxoplasmosis, Congenital - complications
Toxoplasmosis, Congenital - physiopathology
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Summary:We reviewed retrospectively seven children with congenital toxoplasmosis and precocious puberty. All seven showed very high levels of LH (25.2-155.0 IU/ml) and FSH (7.1-38.2) upon stimulation with GnRH. Three of them showed low GH response to an insulin tolerance test. All the children had severe mental retardation. We emphasize that children with congenital toxoplasmosis should have their hypothalamopituitary function evaluated even in subclinical situations that could be responsible for endocrinological disturbances such as precocious puberty.
Bibliography:ark:/67375/QT4-N94N29ZX-0
jpem.2002.15.9.1487.pdf
ArticleID:JPEM.2002.15.9.1487
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ISSN:0334-018X
2191-0251
DOI:10.1515/JPEM.2002.15.9.1487