Methemoglobinemia and Delayed Encephalopathy After 5-Bromo-2-Nitropyridine Poisoning: A Rare Case Report

5-bromo-2-nitropyridine, an intermediate in the synthesis of pharmaceutical and pesticide products, is toxic to the human body. However, 5-bromo-2-nitropyridine poisoning has not been previously reported. Here, we report the case of a 40-year-old man who suffered skin and respiratory tract exposure...

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Published inFrontiers in public health Vol. 10
Main Authors Shi, Longke, Yu, Guangcai, Zhao, Liwen, Wen, Zixin, Li, Yaqian, Kan, Baotian, Jian, Xiangdong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 07.07.2022
Subjects
5-bromo-2-nitropyridine
acute renal failure
hemolytic anemia
methemoglobinemia
Public Health
rhabdomyolysis
toxic encephalopathy
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Summary:5-bromo-2-nitropyridine, an intermediate in the synthesis of pharmaceutical and pesticide products, is toxic to the human body. However, 5-bromo-2-nitropyridine poisoning has not been previously reported. Here, we report the case of a 40-year-old man who suffered skin and respiratory tract exposure to leaked 5-Bromo-2-nitropyridine at work. After exposure, the patient rapidly developed dizziness, fatigue, nausea, vomiting, chest distress, diffuse cyanosis, and coma. Methemoglobinemia, hemolytic anemia, rhabdomyolysis, and acute renal failure were observed after admission. He improved markedly after treatment, but delayed encephalopathy was confirmed 82 days after the exposure. This case highlights that 5-bromo-2-nitropyridine can be absorbed through the skin and respiratory tract, resulting in methemoglobinemia and delayed encephalopathy.
Bibliography:Reviewed by: Jou-Fang Deng, Taipei Veterans General Hospital, Taiwan; Yasser Wali, Sultan Qaboos University, Oman
Edited by: Mohamed A. Yassin, Hamad Medical Corporation, Qatar
These authors have contributed equally to this work and share first authorship
This article was submitted to Occupational Health and Safety, a section of the journal Frontiers in Public Health
ISSN:2296-2565
2296-2565
DOI:10.3389/fpubh.2022.942003