Biotechnological production of healthful conjugated fatty acids
Conjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be produced using biotechnology. Current efforts are aimed at improving the biotransformation process and capability for de novo biosynthesis. The...
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| Published in | Trends in biotechnology (Regular ed.) |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ltd
18.07.2025
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| ISSN | 0167-7799 1879-3096 1879-3096 |
| DOI | 10.1016/j.tibtech.2025.07.005 |
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| Abstract | Conjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be produced using biotechnology. Current efforts are aimed at improving the biotransformation process and capability for de novo biosynthesis. The next step is to make the process even more competitive.
Conjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be produced using biotechnology. Current efforts are aimed at improving the biotransformation process and capability for de novo biosynthesis. The next step is to make the process even more competitive. |
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| AbstractList | Conjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be produced using biotechnology. Current efforts are aimed at improving the biotransformation process and capability for de novo biosynthesis. The next step is to make the process even more competitive.
Conjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be produced using biotechnology. Current efforts are aimed at improving the biotransformation process and capability for de novo biosynthesis. The next step is to make the process even more competitive. Conjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be produced using biotechnology. Current efforts are aimed at improving the biotransformation process and capability for de novo biosynthesis. The next step is to make the process even more competitive. Conjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be produced using biotechnology. Current efforts are aimed at improving the biotransformation process and capability for de novo biosynthesis. The next step is to make the process even more competitive.Conjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be produced using biotechnology. Current efforts are aimed at improving the biotransformation process and capability for de novo biosynthesis. The next step is to make the process even more competitive. AbstractConjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be produced using biotechnology. Current efforts are aimed at improving the biotransformation process and capability for de novo biosynthesis. The next step is to make the process even more competitive. |
| Author | Ji, Xiao-Jun Zhao, Quanyu Huang, He Lin, Lu |
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| Cites_doi | 10.1016/j.ymben.2020.08.011 10.1128/MMBR.00019-18 10.1111/j.1472-765X.2007.02135.x 10.1021/acs.jafc.2c08967 10.1016/j.plipres.2023.101257 10.1021/acs.jafc.3c08718 10.1016/j.biotechadv.2024.108435 10.1186/1475-2859-12-70 10.1007/s10529-016-2175-3 10.3390/molecules24091753 10.1016/j.biotechadv.2019.107454 10.1007/s00253-017-8240-6 10.1186/1475-2859-11-51 10.1021/acs.jafc.1c03256 10.1021/acs.jafc.2c02242 |
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| Keywords | de novo biosynthesis conjugated linoleic acid biotransformation conjugated fatty acid conjugated linolenic acid |
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| References | Zhang (bb0045) 2012; 11 Zhang (bb0035) 2016; 38 Van Nieuwenhove (bb0020) 2007; 44 Gong (bb0005) 2019; 37 Garaiova (bb0075) 2023; 71 Zhang (bb0040) 2022; 70 Wang (bb0065) 2021; 69 Imatoukene (bb0050) 2017; 101 Salsinha (bb0025) 2018; 82 Xu (bb0060) 2020; 62 Wang (bb0070) 2024; 72 Wang (bb0015) 2024; 76 Zhang (bb0030) 2013; 12 Wang (bb0055) 2019; 24 Wu (bb0010) 2024; 93 Zhang (10.1016/j.tibtech.2025.07.005_bb0040) 2022; 70 Van Nieuwenhove (10.1016/j.tibtech.2025.07.005_bb0020) 2007; 44 Wu (10.1016/j.tibtech.2025.07.005_bb0010) 2024; 93 Zhang (10.1016/j.tibtech.2025.07.005_bb0030) 2013; 12 Zhang (10.1016/j.tibtech.2025.07.005_bb0045) 2012; 11 Wang (10.1016/j.tibtech.2025.07.005_bb0070) 2024; 72 Salsinha (10.1016/j.tibtech.2025.07.005_bb0025) 2018; 82 Wang (10.1016/j.tibtech.2025.07.005_bb0065) 2021; 69 Imatoukene (10.1016/j.tibtech.2025.07.005_bb0050) 2017; 101 Garaiova (10.1016/j.tibtech.2025.07.005_bb0075) 2023; 71 Wang (10.1016/j.tibtech.2025.07.005_bb0015) 2024; 76 Zhang (10.1016/j.tibtech.2025.07.005_bb0035) 2016; 38 Xu (10.1016/j.tibtech.2025.07.005_bb0060) 2020; 62 Wang (10.1016/j.tibtech.2025.07.005_bb0055) 2019; 24 Gong (10.1016/j.tibtech.2025.07.005_bb0005) 2019; 37 |
| References_xml | – volume: 93 year: 2024 ident: bb0010 article-title: Advances in research on microbial conjugated linoleic acid bioconversion publication-title: Prog. Lipid Res. – volume: 62 start-page: 20 year: 2020 end-page: 29 ident: bb0060 article-title: Punicic acid production in publication-title: Metab. Eng. – volume: 38 start-page: 1917 year: 2016 end-page: 1922 ident: bb0035 article-title: Production of trans-10, cis-12-conjugated linoleic acid using permeabilized whole-cell biocatalyst of publication-title: Biotechnol. Lett. – volume: 70 start-page: 8377 year: 2022 end-page: 8384 ident: bb0040 article-title: Engineering the β-oxidation pathway in publication-title: J. Agric. Food Chem. – volume: 82 year: 2018 ident: bb0025 article-title: Microbial production of conjugated linoleic acid and conjugated linolenic acid relies on a multienzymatic system publication-title: Microbiol. Mol. Biol. Rev. – volume: 11 start-page: 51 year: 2012 ident: bb0045 article-title: synthesis of trans-10, cis-12 conjugated linoleic acid in oleaginous yeast publication-title: Microb. Cell Factories – volume: 24 start-page: 1753 year: 2019 ident: bb0055 article-title: Modulating heterologous pathways and optimizing culture conditions for biosynthesis of trans-10, cis-12 conjugated linoleic acid in publication-title: Molecules – volume: 76 year: 2024 ident: bb0015 article-title: Biotechnological advances in the production of unusual fatty acids in transgenic plants and recombinant microorganisms publication-title: Biotechnol. Adv. – volume: 37 year: 2019 ident: bb0005 article-title: Production of conjugated fatty acids: a review of recent advances publication-title: Biotechnol. Adv. – volume: 71 start-page: 3842 year: 2023 end-page: 3851 ident: bb0075 article-title: Heterologous production of calendic acid naturally found in publication-title: J. Agric. Food Chem. – volume: 69 start-page: 9616 year: 2021 end-page: 9624 ident: bb0065 article-title: Improving the production of punicic acid in baker’s yeast by engineering genes in acyl channeling processes and adjusting precursor supply publication-title: J. Agric. Food Chem. – volume: 44 start-page: 467 year: 2007 end-page: 474 ident: bb0020 article-title: Conjugated linoleic acid conversion by dairy bacteria cultured in MRS broth and buffalo milk publication-title: Lett. Appl. Microbiol. – volume: 12 start-page: 70 year: 2013 ident: bb0030 article-title: Genetic engineering of publication-title: Microb. Cell Factories – volume: 72 start-page: 3088 year: 2024 end-page: 3098 ident: bb0070 article-title: Engineering publication-title: J. Agric. Food Chem. – volume: 101 start-page: 4605 year: 2017 end-page: 4616 ident: bb0050 article-title: A metabolic engineering strategy for producing conjugated linoleic acids using the oleaginous yeast publication-title: Appl. Microbiol. Biotechnol. – volume: 62 start-page: 20 year: 2020 ident: 10.1016/j.tibtech.2025.07.005_bb0060 article-title: Punicic acid production in Brassica napus publication-title: Metab. Eng. doi: 10.1016/j.ymben.2020.08.011 – volume: 82 year: 2018 ident: 10.1016/j.tibtech.2025.07.005_bb0025 article-title: Microbial production of conjugated linoleic acid and conjugated linolenic acid relies on a multienzymatic system publication-title: Microbiol. Mol. Biol. Rev. doi: 10.1128/MMBR.00019-18 – volume: 44 start-page: 467 year: 2007 ident: 10.1016/j.tibtech.2025.07.005_bb0020 article-title: Conjugated linoleic acid conversion by dairy bacteria cultured in MRS broth and buffalo milk publication-title: Lett. Appl. Microbiol. doi: 10.1111/j.1472-765X.2007.02135.x – volume: 71 start-page: 3842 year: 2023 ident: 10.1016/j.tibtech.2025.07.005_bb0075 article-title: Heterologous production of calendic acid naturally found in Calendula officinalis by recombinant fission yeast publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.2c08967 – volume: 93 year: 2024 ident: 10.1016/j.tibtech.2025.07.005_bb0010 article-title: Advances in research on microbial conjugated linoleic acid bioconversion publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2023.101257 – volume: 72 start-page: 3088 year: 2024 ident: 10.1016/j.tibtech.2025.07.005_bb0070 article-title: Engineering Yarrowia lipolytica for sustainable production of the pomegranate seed oil-derived punicic acid publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.3c08718 – volume: 76 year: 2024 ident: 10.1016/j.tibtech.2025.07.005_bb0015 article-title: Biotechnological advances in the production of unusual fatty acids in transgenic plants and recombinant microorganisms publication-title: Biotechnol. Adv. doi: 10.1016/j.biotechadv.2024.108435 – volume: 12 start-page: 70 year: 2013 ident: 10.1016/j.tibtech.2025.07.005_bb0030 article-title: Genetic engineering of Yarrowia lipolytica for enhanced production of trans-10, cis-12 conjugated linoleic acid publication-title: Microb. Cell Factories doi: 10.1186/1475-2859-12-70 – volume: 38 start-page: 1917 year: 2016 ident: 10.1016/j.tibtech.2025.07.005_bb0035 article-title: Production of trans-10, cis-12-conjugated linoleic acid using permeabilized whole-cell biocatalyst of Yarrowia lipolytica publication-title: Biotechnol. Lett. doi: 10.1007/s10529-016-2175-3 – volume: 24 start-page: 1753 year: 2019 ident: 10.1016/j.tibtech.2025.07.005_bb0055 article-title: Modulating heterologous pathways and optimizing culture conditions for biosynthesis of trans-10, cis-12 conjugated linoleic acid in Yarrowia lipolytica publication-title: Molecules doi: 10.3390/molecules24091753 – volume: 37 year: 2019 ident: 10.1016/j.tibtech.2025.07.005_bb0005 article-title: Production of conjugated fatty acids: a review of recent advances publication-title: Biotechnol. Adv. doi: 10.1016/j.biotechadv.2019.107454 – volume: 101 start-page: 4605 year: 2017 ident: 10.1016/j.tibtech.2025.07.005_bb0050 article-title: A metabolic engineering strategy for producing conjugated linoleic acids using the oleaginous yeast Yarrowia lipolytica publication-title: Appl. Microbiol. Biotechnol. doi: 10.1007/s00253-017-8240-6 – volume: 11 start-page: 51 year: 2012 ident: 10.1016/j.tibtech.2025.07.005_bb0045 article-title: De novo synthesis of trans-10, cis-12 conjugated linoleic acid in oleaginous yeast Yarrowia lipolytica publication-title: Microb. Cell Factories doi: 10.1186/1475-2859-11-51 – volume: 69 start-page: 9616 year: 2021 ident: 10.1016/j.tibtech.2025.07.005_bb0065 article-title: Improving the production of punicic acid in baker’s yeast by engineering genes in acyl channeling processes and adjusting precursor supply publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.1c03256 – volume: 70 start-page: 8377 year: 2022 ident: 10.1016/j.tibtech.2025.07.005_bb0040 article-title: Engineering the β-oxidation pathway in Yarrowia lipolytica for the production of trans-10, cis-12-conjugated linoleic acid publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.2c02242 |
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| Snippet | Conjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can alternatively be... AbstractConjugated fatty acids (CFAs) are important for human health. They are traditionally obtained by extraction or chemical synthesis, but can... |
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| Title | Biotechnological production of healthful conjugated fatty acids |
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