Outbreak of Poliomyelitis in Gizan, Saudi Arabia: Cocirculation of Wild Type 1 Polioviruses from Three Separate Origins

In 1989, a localized outbreak of 10 cases of poliomyelitis occurred in Saudi Arabia. Wild poliovirus type 1 was isolated from 5 patients. To determine the patterns of poliovirus circulation, partial nucleotide sequences of the poliovirus isolates were compared. These isolates were remarkably diverse...

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Published inThe Journal of infectious diseases Vol. 175; no. Supplement-1; pp. S71 - S75
Main Authors Afif, Huda, Sutter, Roland W., Kew, Olen M., Fontaine, Robert E., Pallansch, Mark A., Goyal, Mahesh K., Cochi, Stephen L.
Format Journal Article
LanguageEnglish
Published United States The University of Chicago Press 01.02.1997
University of Chicago Press
Subjects
Child
Child, Preschool
Current Status of Poliomyelitis
Disease eradication
Disease Outbreaks
Epidemiology
Female
Genotypes
Humans
Immunization
Infant
Male
Oral poliovirus vaccine
Polio
Poliomyelitis
Poliomyelitis - epidemiology
Poliomyelitis - immunology
Poliomyelitis - virology
Poliovirus
Poliovirus - classification
Poliovirus - isolation & purification
Poliovirus Vaccine, Oral - immunology
Preventive medicine
Saudi Arabia - epidemiology
Saudi Arabia
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Summary:In 1989, a localized outbreak of 10 cases of poliomyelitis occurred in Saudi Arabia. Wild poliovirus type 1 was isolated from 5 patients. To determine the patterns of poliovirus circulation, partial nucleotide sequences of the poliovirus isolates were compared. These isolates were remarkably diverse. Two isolates were closely related to each other and to viruses isolated during the 1988 epidemic in Oman. Two other isolates were very similar to viruses found in Egypt. The fifth isolate was distantly related to the latter pair. The molecular data suggest that the 10 cases represented three separate outbreaks. The virologic findings underscore the potential for Saudi Arabia, which receives millions of guest workers and their families each year from countries in which polio is endemic, to be exposed to frequent importations of wild polioviruses. To restrict the circulation of imported polioviruses, Saudi Arabia must maintain high population immunity to poliovirus in all geopolitical divisions.
Bibliography:istex:34D7EED4526A4652CFE65411EB5B5F1403D09629
Reprints or correspondence: Dr. Roland W. Sutter, Information Services, National Immunization Program (E34), Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
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ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/175.Supplement_1.S71