Simvastatin-induced lupus erythematosus

We report the case of a 79-year-old man who had onset of fatigue, myalgia, and pleuritic chest pain 3 months after initiation of therapy with simvastatin. He had signs of pleuropericarditis due to simvastatin-induced lupus erythematosus. This should alert clinicians to this possible adverse effect o...

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Bibliographic Details
Published inSouthern medical journal (Birmingham, Ala.) Vol. 91; no. 9; pp. 873 - 874
Main Authors KHOSLA, R, BUTMAN, A. N, HAMMER, D. F
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 01.09.1998
Subjects
Aged
Anticholesteremic Agents - adverse effects
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Humans
Lupus Erythematosus, Systemic - chemically induced
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Simvastatin - adverse effects
Human
Immunopathology
Connective tissue disease
Skin disease
Enzyme
Toxicity
Simvastatin
Enzyme inhibitor
Autoimmune disease
Metabolic diseases
Lipids
Hyperlipoproteinemia
Case study
Chemotherapy
Hypercholesterolemia
Treatment
Systemic disease
Hydroxymethylglutaryl-CoA reductase
Lupus erythematosus
Oxidoreductases
Disseminated
Dyslipemia
Antilipemic agent
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Summary:We report the case of a 79-year-old man who had onset of fatigue, myalgia, and pleuritic chest pain 3 months after initiation of therapy with simvastatin. He had signs of pleuropericarditis due to simvastatin-induced lupus erythematosus. This should alert clinicians to this possible adverse effect of simvastatin and other statins.
ISSN:0038-4348
1541-8243
DOI:10.1097/00007611-199809000-00016