Preparation and characterization of double crosslinked hydrogel films from carboxymethylchitosan and carboxymethylcellulose

• Published in: Carbohydrate polymers Vol. 110; pp. 113 - 120
• Main Authors: Bao, Dengshan, Chen, Mingjie, Wang, Haiying, Wang, Jufang, Liu, Chuanfu, Sun, Runcang
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 22.09.2014
• Subjects: Applied sciences; Carboxymethylcellulose Sodium - chemical synthesis; Carboxymethylcellulose Sodium - metabolism; Chitosan - analogs & derivatives; Chitosan - chemical synthesis; Chitosan - metabolism; Cross-Linking Reagents - chemical synthesis; Cross-Linking Reagents - metabolism; Exact sciences and technology; Methylgalactosides - chemical synthesis; Methylgalactosides - metabolism; Natural polymers; Physicochemistry of polymers; Starch and polysaccharides; Biological properties; Cellulose(carboxymethyl); Swelling; Film; Gelation; Aglycone; Mechanical properties; Cytotoxicity; Experimental study; Property processing relationship; In vitro; Carboxymethylchitosan; Colloidal gel; Polyelectrolyte; Calcium ion; Double crosslinking; Chitosan derivatives; Preparation; pH; Oside polymer; Polyacid; Hydrogel; Carboxymethylcellulose; Cellulose ether
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2014.03.095

A novel crosslinked hydrogel film was prepared from carboxymethylchitosan (CMCS) and carboxymethylcellulose (CMC) by ionical and covalent crosslinking with CaSO4 and genipin, respectively. The swelling ratio of the crosslinked CMCS/CMC hydrogel films was investigated at different pH solutions (1-9), and the results indicated that the crosslinked hydrogels had the swelling-deswelling properties with two primary peaks of swelling ratio at pH 3 and 7. The surface morphologies of the crosslinked hydrogels at different pH values provided evidences of the swelling-deswelling properties. The mechanical properties of the hydrogel films were also examined. The ionical and covalent crosslinking were found to have the primary impact on the toughness and max load, respectively, of the crosslinked hydrogels. The cells comparatively cultured on the crosslinked hydrogels and the negative and positive controls suggested the biocompatibility of the crosslinked CMCS/CMC films. This kind of hydrogel films have potential application in drug delivery vehicles and skin tissue engineering.