Lung function in school-aged asthmatic children with inhaled cromoglycate, nedocromil and corticosteroid therapy

• Published in: The European respiratory journal Vol. 13; no. 1; pp. 82 - 86
• Main Authors: Korhonen, K, Korppi, M, Remes, ST, Reijonen, TM, Remes, K
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.01.1999; Maney
• Subjects: Administration, Inhalation; Adrenal Cortex Hormones - administration & dosage; Anti-Asthmatic Agents - administration & dosage; Asthma - drug therapy; Asthma - physiopathology; Biological and medical sciences; Child; Cromolyn Sodium - administration & dosage; Female; Forced Expiratory Volume - drug effects; Humans; Male; Maximal Expiratory Flow Rate - drug effects; Medical sciences; Nedocromil - administration & dosage; Peak Expiratory Flow Rate - drug effects; Pharmacology. Drug treatments; Respiratory system; Human; Corticosteroid; Nedocromil; Drug combination; Respiratory disease; Treatment efficiency; Asthma; Inhalation; Chemotherapy; Lung function; Treatment; Obstructive pulmonary disease; Child
• ISSN: 0903-1936; 1399-3003
• DOI: 10.1183/09031936.99.13108399

Two-thirds of the children with asthma in our area use cromones and only one-third steroids as the maintenance therapy. This study aimed to evaluate our treatment policy based on the international consensus. Peak expiratory flow (PEF), dynamic spirometry and bronchodilation test results were therefore collected in 195 school-aged patients who visited our outpatient clinic in 1995. Sixty-four children (33%) used cromoglycate, 86 (44%) nedocromil and 45 (23%) inhaled steroids. Twenty-five (12%) needed combination therapy, mainly with salmeterol. Lung function results were good, and there were no significant differences between the therapeutic groups irrespective of whether pre- or postbronchodilator values were considered. PEF was decreased in eight (4%), forced expiratory volume in one second (FEVI) in four (2%) and maximum mid-expiratory flow (MMEF) in 33 (17%) patients. At least one result was decreased in 39 (20%) cases, in most cases (77%) MMEF alone. Significant rises after salbutamol inhalations were observed in 17 (9%) in PEF, in two (1%) in FEV1 and 20 (10%) in MMEF values. Thus, the bronchodilation test was positive in 33 (17%) cases, and in 22 (11%) cases it was the only sign of bronchial obstruction. Over 70% of the children with asthma can be treated with cromones by a stepwise treatment modality. Inhaled steroids can be restricted to those not controllable by cromones. Lung function tests, including postbronchodilator values, should be part of the follow-up of continuous maintenance medication for asthma.