Osteoradionecrosis of mandible bone in patients with oral cancer-associated factors and treatment outcomes
Background The purpose of this study was to investigate factors associated with osteoradionecrosis (ORN) of the mandible bone in a large cohort of patients with oral cancer. Methods We reviewed the medical records of patients with oral cancer and identified those with ORN of the mandible bone. Varia...
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Published in | Head & neck Vol. 38; no. 5; pp. 762 - 768 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.05.2016
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Background
The purpose of this study was to investigate factors associated with osteoradionecrosis (ORN) of the mandible bone in a large cohort of patients with oral cancer.
Methods
We reviewed the medical records of patients with oral cancer and identified those with ORN of the mandible bone. Variables of patients with and without ORN were compared and associated factors were investigated by logistic regression model.
Results
A total of 1692 patients were included in the final analysis and 105 patients (6.2%) developed ORN in the mandible bone. Primary site, including mouth floor, buccal mucosa, retromolar trigone, or gum, segmental mandibulectomy, and total radiation dose to the primary site ≥75 Gy were independent factors associated with ORN. After aggressive treatment using surgical intervention with/without hyperbaric oxygen, 93.3% of the patients healed completely.
Conclusion
Among patients with oral cancer after radiation, ORN is an uncommon and dreaded complication. Recognition of associated factors can help physicians to identify those at risk. © 2015 Wiley Periodicals, Inc. Head Neck 38: 762–768, 2016 |
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Bibliography: | ark:/67375/WNG-QT83D5G1-N ArticleID:HED23949 The study was partially supported by grants from Taichung Veterans General Hospital (TCVGH - 1037003C), Taichung, Taiwan, Republic of China. istex:EDE1409D42EE835DCFF310B20621EF075322CD02 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1043-3074 1097-0347 |
DOI: | 10.1002/hed.23949 |