Mitigating the impact of mechanisms causing neuronal degeneration

• Published in: Neuroprotection (Chichester, England. Online) Vol. 2; no. 1; pp. 1 - 3
• Main Authors: Ji, Xunming, Walczak, Piotr, Boltze, Johannes
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2024; Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China%Center for Advanced Imaging Research, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA%School of Life Sciences, University of Warwick, Coventry, UK; Wiley
• Subjects: Alzheimer's disease; Brain research; Clinical trials; Dementia; Disease; Edema; extracellular vesicles; intracranial pressure; Ischemia; Metabolism; microglia; Multiple sclerosis; Neurodegeneration; Pathogenesis; stem cells; stress; Stroke; vascular dementia; stem cells; stress; extracellular vesicles; Alzheimer’s disease; intracranial pressure; vascular dementia; neurodegeneration; microglia; stroke; Alzheimer's disease
• ISSN: 2770-730X; 2770-7296; 2770-730X
• DOI: 10.1002/nep3.41

Addressing multiple neurodegenerative mechanisms may be a more viable strategy. [...]the restoration of lost brain tissue turned out to be a very complex endeavor. Since many of the mechanistic investigations reviewed were conducted in animal models of Alzheimer's disease, the translatability of these findings to human patients remains to be shown. [...]the role of Tc17 cells in multiple sclerosis needs to be elucidated in future translational studies.