Myoglobin concentrations and muscle-enzyme activities in serum after myocardial infarction and cardiac arrhythmia

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 23; no. 5; pp. 868 - 870
• Main Authors: Rosano, T G, Sanders, L A, Johnson, E S, Kenny, M A, Clayson, K J, Strandjord, P E
• Format: Journal Article
• Language: English
• Published: England 01.05.1977
• Subjects: Arrhythmias, Cardiac - blood; Arrhythmias, Cardiac - enzymology; Creatine Kinase - blood; Humans; Isoenzymes - blood; L-Lactate Dehydrogenase - blood; Myocardial Infarction - blood; Myocardial Infarction - enzymology; Myoglobin - blood; Time Factors
• ISSN: 0009-9147; 1530-8561
• DOI: 10.1093/clinchem/23.5.868

Sera from patients with myocardial infarction and cardiac arrhythmias were analyzed for myoglobin concentration and the activities of total creatine kinase, creatine kinase isoenzyme-2, and lactate dehydrogenase isoenzyme-1 at the time of hospital admission and during the first few days of hospitalization. The nine patients with a final diagnosis of myocardial infarction had abnormally high values for total creatine kinase, creatine kinase-2, lactate dehydrogenase-1, and myoglobin. Myoglobin concentrations were highest on admission in six patients and on the day after admission in the other three patients. Creatine kinase-2 manifested maximum activity on the day after admission for all patients with myocardial infarction. Lactate dehydrogenase-1 did not reach maximal values until the second or third day after admission. The six patients with arrhythmias did not show any significant increases in creatine kinase-2 or lactate dehydrogenase-1. Myoglobin and total creatine kinase, however, were increased in the four patients who had received cardioversion. The specificity and diagnostic usefulness of these serum measurements are discussed.