Potential role of antitachycardia pacing alerts for the reduction of emergency presentations following shocks in patients with implantable cardioverter-defibrillators: implications for the implementation of remote monitoring

• Published in: Europace (London, England) Vol. 18; no. 12; pp. 1809 - 1817
• Main Authors: Boulé, Stéphane, Ninni, Sandro, Finat, Loïc, Botcherby, Edward J, Kouakam, Claude, Klug, Didier, Marquié, Christelle, Brigadeau, François, Lacroix, Dominique, Kacet, Salem, Guédon-Moreau, Laurence
• Format: Journal Article
• Language: English
• Published: England 01.12.2016
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Cardiac Pacing, Artificial - adverse effects; Defibrillators, Implantable; Electric Countershock - adverse effects; Electric Countershock - instrumentation; Electrocardiography; Emergency Medical Services; Female; France; Humans; Logistic Models; Male; Middle Aged; Monitoring, Physiologic - methods; Multivariate Analysis; Myocardial Ischemia - epidemiology; Myocardial Ischemia - etiology; Prospective Studies; Remote Sensing Technology; Tachycardia, Ventricular - therapy; Telemedicine; Ventricular Dysfunction, Left - epidemiology; Ventricular Dysfunction, Left - etiology; Young Adult; Shock; Alerts; Telemedicine; Antitachycardia pacing; Implantable cardioverter-defibrillator; Remote monitoring
• ISSN: 1099-5129; 1532-2092
• DOI: 10.1093/europace/euv392

Despite increased use of remote monitoring (RM) to follow up implantable cardioverter-defibrillator (ICD) recipients, many patients still receive ICD shocks in the community and present to the emergency department. Our aim was to identify the best predictors of impending shock delivery that can be measured with an ICD and to identify the most appropriate activities to alert physicians to during RM follow-up. All patients presenting to our institution for ICD shock, from November 2011 to November 2014, were enrolled in this prospective study. Patient characteristics, investigation results, and details of electrical activities from ICD interrogation were recorded at presentation. Presentations were classified as potentially avoidable if activities from a list of set criteria were apparent more than 48 h before index shock. Univariate and multivariate analyses were then used to identify predictors of potentially avoidable shocks. In total, 109 emergency presentations were recorded in 90 patients (male: 85%; 57 ± 16 years; ischaemic cardiomyopathy: 49%; LVEF: 34 ± 13%; electrical storm: 40%), of which 26 (24%) were potentially avoidable. Antitachycardia pacing (ATP) episodes were the most important predictor of impending shock. Potentially avoidable shocks were preceded by more episodes of ATP than unavoidable shocks (13 [3-67] vs. 3 [0-10]; P < 0.001). Patients followed up with RM systems configured to generate alerts following ATP delivery experienced significantly less ICD shocks (24 vs. 16%, P < 0.01). Remote monitoring systems that generate alerts following ATP delivery could reduce emergency presentations for ICD shock by 24%, as ATP is a key predictor of impending shock delivery.