Synthesis of the chiral intermediate of batzelladines A and B

The title compound (S, Z)-methyl 2-[3-(tert-butyldimethylsilyloxy)pyrrolidin-2-ylidene]acetate(6) has been stereoselectively synthesized by the Reformatsky coupling reaction, and the absolute configuration of 6 was determined by 1 H NMRand single-crystal X-ray diffraction.

Saved in:
Bibliographic Details
Published inPhosphorus, sulfur, and silicon and the related elements Vol. 192; no. 1; pp. 113 - 117
Main Authors Guo, Yongbiao, Gao, Zhenhua, Huang, Guilan, Zhong, Hui, Meng, Xiangyan, Tang, Hui, Zou, Chuanpin
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 01.01.2017
Taylor & Francis Ltd
Subjects
Batzelladines A and B
Chemical industry
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Crystals
Diffraction
enantioselective synthesis
Eschenmoser coupling reaction
Physical Sciences
Reformatsky coupling reaction
Science & Technology
enantioselective synthesis
Reformatsky coupling reaction
Eschenmoser coupling reaction
Batzelladines A and B
MODEL
Online AccessGet full text

Cover

More Information
Summary:The title compound (S, Z)-methyl 2-[3-(tert-butyldimethylsilyloxy)pyrrolidin-2-ylidene]acetate(6) has been stereoselectively synthesized by the Reformatsky coupling reaction, and the absolute configuration of 6 was determined by 1 H NMRand single-crystal X-ray diffraction.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2016.1231190