The interaction of copper(II) with a lipotetrapeptide

The lauroyl tetrapeptide N 2- [ N-( N-lauroyl-L- alanyl)-α-D-glutamyl] N 6-(glycyl-) DD, LL-2,6-diaminopimelamic acid (LTP-DAP) has been shown by potentiometry and spectroscopy to interact with Cu(II) to form the complexes [CuL], [CuLH /t-1], [CuLH −2] and, at high pH, possibly [CuLH −3] also. Stabi...

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Bibliographic Details
Published inInorganica Chimica Acta Vol. 136; no. 3; pp. 173 - 176
Main Authors Decock-Le Reverend, B., Loucheux, C., Livera, C., Pettit, L.D., Migliore-Samour, D., Jolles, P.
Format Journal Article
LanguageEnglish
Published Lausanne Elsevier B.V 01.06.1987
Elsevier Science
Subjects
Chemistry
Coordination compounds
Exact sciences and technology
Inorganic chemistry and origins of life
Preparations and properties
Divalent metal Complexes
Copper II Complexes
Tripeptide
Organic ligand
Chemical composition
Stability constant
Transition metal Complexes
Formation
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Summary:The lauroyl tetrapeptide N 2- [ N-( N-lauroyl-L- alanyl)-α-D-glutamyl] N 6-(glycyl-) DD, LL-2,6-diaminopimelamic acid (LTP-DAP) has been shown by potentiometry and spectroscopy to interact with Cu(II) to form the complexes [CuL], [CuLH /t-1], [CuLH −2] and, at high pH, possibly [CuLH −3] also. Stability constants have been measured at 25 °C and an ionic strength of 0.10 mol dm −3 (KNO 3). Stereoselectivity between the diastereoisomers of the ligand was found to be small, probably as a result of the flexibility of the ligand molecule.
ISSN:0020-1693
1873-3255
DOI:10.1016/S0020-1693(00)81150-0