Co(III), Ni(II) and Cu(II) complexes with a tetradentate Schiff base ligand: synthesis, characterization, electrochemical behavior, binding assessment and in vitro cytotoxicity

• Published in: Journal of coordination chemistry Vol. 75; no. 1-2; pp. 211 - 224
• Main Authors: Mirković, Marija, Radović, Magdalena, Stanković, Dalibor, Vranješ-Đurić, Sanja, Janković, Drina, Petrović, Djordje, Mihajlović-Lalić, Ljiljana E., Prijović, Željko, Milanović, Zorana
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis 17.01.2022; Taylor & Francis Ltd
• Subjects: anticancer activity; Anticancer properties; Binding; Chemical analysis; Cobalt; Colon; Coordination compounds; Copper; Cytotoxicity; Deoxyribonucleic acid; Diketones; DNA; DNA interaction; Electroactivity; Electrochemical analysis; electrochemical behavior; Electrochemistry; HSA binding; Imines; Infrared spectroscopy; Ligands; Mass spectrometry; metal complex; Nickel; Schiff base ligand; Serum albumin; Spectrophotometry; Toxicity
• ISSN: 0095-8972; 1029-0389
• DOI: 10.1080/00958972.2022.2032683

Two new Schiff base cobalt(III) ([Co(LH)Cl 2 ], 1) and nickel(II) ([Ni(LH)ClO 4 ], 2) complexes with a diimine-dioxime ligand, (4,9-diaza-3,10-diethyl-3,9-dodecadiene-2,11-dione bis oxime (LH 2 )), were synthesized and characterized. The compounds were obtained in MeOH from corresponding metal salts and LH 2 in molar ratio 1:1 and further characterized by mass spectrometry, IR spectroscopy, electrochemistry, and elemental analysis. Previously reported copper(II) analog ([Cu 2 (LH) 2 ]·(ClO 4 ) 2 , 3) was joined to 1 and 2, and the three metal analogs, 1-3, were further investigated in terms of their electrochemical behavior. Binding studies of the complexes with deoxyribonucleic acid (DNA) and human serum albumin (HSA) were carried out using both spectrophotometric and electrochemical methods. All three complexes exhibit binding affinity towards the DNA chain through intercalative interactions. The binding reaction with HSA showed for 1 and 3 decrease in the peak current obtained in the case of complexes before the addition of HSA, while the Ni complex-HSA possesses the same electroactivity as starting complex. The cytotoxicity of LH 2 as well as its metal complexes, and cisplatin were evaluated on CT-26 mouse colon carcinoma and human LS174T cancer cell lines employing MTT assay. The copper(II) complex exhibited very promising anticancer activity compared with cisplatin.