REVIEW: Biomedical applications of Schiff base metal complexes

Metal complexes of Schiff bases synthesized from condensation of an amine with carbonyl compounds are widely used for industrial purposes such as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers, and corrosion inhibitors. For design and development of various bio...

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Published inJournal of coordination chemistry Vol. 73; no. 23; pp. 3109 - 3149
Main Authors Uddin, Mohammad Nasir, Ahmed, Sayeda Samina, Alam, S. M. Rahatul
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 01.12.2020
Taylor & Francis Ltd
Subjects
Antiinfectives and antibacterials
Base metal
Biological activity
biomedical applications
Biomedical materials
Carbonyl compounds
Carbonyls
Chemical synthesis
Chemists
Coordination compounds
Corrosion inhibitors
Functional groups
Fungicides
Imines
Metal complexes
Pharmacology
Pigments
Schiff bases
Stabilizers (agents)
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Summary:Metal complexes of Schiff bases synthesized from condensation of an amine with carbonyl compounds are widely used for industrial purposes such as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers, and corrosion inhibitors. For design and development of various bioactive compounds, Schiff bases carrying imine or azomethine (−C = N-) functional group, are versatile pharmacophores. Medicinal chemists give attention toward new chemotherapeutic Schiff bases and their metal complexes owing to numerous applications in pharmacology as antiviral, antibacterial, antifungal, antimalarial, antituberculosis, anticancer, anti-HIV, anti-inflammatory, and antipyretic agents. This review highlights recently synthesized Schiff bases as well as their metal complexes as potential bioactive core.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2020.1854745