Bioavailability Study on a New Slow-Release Formulation of Ketoprofen

• Published in: Journal of international medical research Vol. 10; no. 4; pp. 229 - 233
• Main Authors: Caruso, I, Frigerio, E, Fumagalli, M, Liverta, C, Moro, L, Tamassia, V
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.1982
• Subjects: Adult; Biological Availability; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; Ketoprofen - metabolism; Kinetics; Male; Metabolic Clearance Rate; Phenylpropionates - metabolism

Four healthy subjects volunteered for a crossover bioavailability study to compare the rate and extent of absorption of plain capsules and new slow-release capsules of ketoprofen. The formulations were administered in two consecutive 4-day periods at the following dose schedules: 2 × 50 mg plain cap...