Bioavailability Study on a New Slow-Release Formulation of Ketoprofen

Four healthy subjects volunteered for a crossover bioavailability study to compare the rate and extent of absorption of plain capsules and new slow-release capsules of ketoprofen. The formulations were administered in two consecutive 4-day periods at the following dose schedules: 2 × 50 mg plain cap...

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Bibliographic Details
Published inJournal of international medical research Vol. 10; no. 4; pp. 229 - 233
Main Authors Caruso, I, Frigerio, E, Fumagalli, M, Liverta, C, Moro, L, Tamassia, V
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.1982
Subjects
Adult
Biological Availability
Delayed-Action Preparations
Drug Administration Schedule
Female
Humans
Ketoprofen - metabolism
Kinetics
Male
Metabolic Clearance Rate
Phenylpropionates - metabolism
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Summary:Four healthy subjects volunteered for a crossover bioavailability study to compare the rate and extent of absorption of plain capsules and new slow-release capsules of ketoprofen. The formulations were administered in two consecutive 4-day periods at the following dose schedules: 2 × 50 mg plain capsules t.i.d. and 150 mg slow-release capsules b.i.d. The plasma levels profile of unchanged ketoprofen was assessed by GLC during the 4th day of treatment with each formulation. The absorption from slow-release capsules was slower and more sustained than from plain capsules but almost complete. The bioavailability properties of new slow-release capsules of ketoprofen appear suitable for clinical use with reduced frequency of daily dosing.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0300-0605
1473-2300
DOI:10.1177/030006058201000407