Potential risk of dental fluorosis associated with different baby formulas and water brands marketed in Spain

• Published in: The Journal of clinical pediatric dentistry Vol. 48; no. 1; pp. 111 - 119
• Main Authors: Gallego-Reyes, Sandra M, Cury, Jaime A, Pérez-Silva, Amparo, Serna-Muñoz, Clara, Fernández-Pizarro, Icíar, Martínez-Beneyto, Yolanda, Ortiz-Ruiz, Antonio J
• Format: Journal Article
• Language: English
• Published: Singapore 01.01.2024
• Subjects: Drinking Water - analysis; Fluorides; Fluorosis, Dental - etiology; Humans; Infant; Infant Formula - adverse effects; Spain; Water Supply; Spain; Bottle feeding; Baby formula; Bottled water; Fluoride intake; Dental fluorosis
• ISSN: 1053-4628
• DOI: 10.22514/jocpd.2024.013

Despite efforts to promote breastfeeding, many babies aged <6 months receive only baby formula reconstituted with bottled water. The intake of high levels of fluoride during amelogenesis has been associated with hypomineralization of the tooth enamel, with aesthetic and mechanical repercussions. The objective of this study was to determine the potential risk of dental fluorosis associated with baby formulas marketed in Spain. We measured 26 baby formulas frequently consumed in Spain; 17 brands for babies aged <6 months, 5 for those aged >6 months, and 4 ready-to-use brands. They were prepared with 4 types of water: distilled water and three brands of bottled water with different levels of fluoride. The fluoride concentration (mg/L or ppm F) was measured with an ion-specific electrode coupled to an ion analyzer. Each sample was prepared according to the manufacturer's instructions and analyzed in triplicate. A descriptive analysis was carried out. The minimum fluoride level found was 0.04 mg/L and the maximum was 1.02 mg/L. Considering the daily intake of these formulas, none exceeded the clinically-acceptable daily dose limit risk for fluorosis (0.07 mg F/day/kg body weight) when mixed with bottled water with a low level of fluoride (0.1 mg/L). However, when the same brands of formula were reconstituted with bottled water with a higher fluoride content (0.99 mg/L), they all exceeded the daily dose limit for the risk of fluorosis. As the potential risk of dental fluorosis associated with the formulas tested depends exclusively on the fluoride concentration of the waters used for reconstitution, formula packaging should contain a warning.