Efficient S-Acylation of Thiourea

Abstract Efficient S -acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively­ on the sulfur atom of thiourea is provided by single-crystal X-ray crystallo...

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Bibliographic Details
Published inSynOpen (2017) Vol. 2; no. 4; pp. 0263 - 0267
Main Authors Jones, David J., Khandavilli, Uday B. Rao, O’Leary, Eileen M., Lawrence, Simon E., O’Sullivan, Timothy P.
Format Journal Article
LanguageEnglish
Published Stuttgart · New York Georg Thieme Verlag 01.10.2018
Georg Thieme Verlag KG
Subjects
isothiourea
letter
organosulfur
sulfur transfer
thiourea
organosulfur
thiourea
isothiourea
sulfur transfer
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Summary:Abstract Efficient S -acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively­ on the sulfur atom of thiourea is provided by single-crystal X-ray crystallographic analysis.
ISSN:2509-9396
2509-9396
DOI:10.1055/s-0037-1610370