Expression of the fos oncogene in B16 melanoma cells exhibiting different metastatic abilities

Expression of the c- fos oncogene in B16 melanoma with high and low metastatic abilities was investigated. In Northern blot analysis, a highly metastatic B16-F10 melanoma cell line showed a higher extent of transcription of the fos gene than did a low metastatic B16-F1 cell line. Immunohistochemical...

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Published inJournal of dermatological science Vol. 1; no. 6; pp. 455 - 458
Main Authors Urabe, Atsumichi, Nakayama, Juichiro, Taniguchi, Shun'ichiro, Inoue, Mitsuse, Hori, Yoshiaki
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ireland Ltd 01.11.1990
Subjects
Animals
Cell Line
fos
Gene Expression Regulation, Neoplastic
Melanoma
Melanoma, Experimental - genetics
Melanoma, Experimental - secondary
Mice
Mice, Inbred C57BL
Oncogene
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-fos
Proto-Oncogenes
Tumor Cells, Cultured - pathology
Oncogene
Melanoma
fos
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Summary:Expression of the c- fos oncogene in B16 melanoma with high and low metastatic abilities was investigated. In Northern blot analysis, a highly metastatic B16-F10 melanoma cell line showed a higher extent of transcription of the fos gene than did a low metastatic B16-F1 cell line. Immunohistochemical studies revealed that B16-F10 cells stained more strongly than B16-F1 cells, both in vitro and in vivo, using the antibody against fos proteins. These results suggest that fos product may be involved in the regulation of gene expressions related to metastasis of B16 melanoma.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0923-1811
1873-569X
DOI:10.1016/0923-1811(90)90016-7