STACKING AND STABILITY OF RNA DUPLEXES CONTAINING FLUOROBENZENE AND FLUOROBENZIMIDAZOLE NUCLEOSIDES

Six different fluorobenzene or fluorobenzimidazole ribonucleosides and one abasic site were incorporated in oligoribonucleotides. Individual contributions of base stacking and solvation of the modified nucleosides could be determined. In fluorobenzene · fluorobenzimidazole-modified base pairs a dupl...

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Bibliographic Details
Published inNucleosides, nucleotides & nucleic acids Vol. 20; no. 4-7; pp. 815 - 818
Main Authors Parsch, Jörg, Engels, Joachim W.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis Group 01.04.2001
Subjects
Benzimidazoles - chemistry
Fluorobenzenes - chemistry
Hydrogen Bonding
Nucleic Acid Conformation
Organophosphorus Compounds - chemistry
Ribonucleosides - chemistry
RNA - chemistry
Solubility
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Summary:Six different fluorobenzene or fluorobenzimidazole ribonucleosides and one abasic site were incorporated in oligoribonucleotides. Individual contributions of base stacking and solvation of the modified nucleosides could be determined. In fluorobenzene · fluorobenzimidazole-modified base pairs a duplex stabilizing force was found that points to a weak F...H hydrogen bond. The lipophilicity of the unprotected nucleosides were investigated by determination of 1-octanol water partition coefficients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-100002436