Thionucleotides as Inhibitors of Ribonucleotide Reductase

Ribonucleosides and xylonucleosides bearing a disulfide function on the sugar ring were synthesized. Ribonucleosides belonging to the cytidine series were found to efficiently reduce dNTP pools in the human lymphoblastoïd CEM/SS cell line.

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Bibliographic Details
Published inNucleosides, nucleotides & nucleic acids Vol. 22; no. 5-8; pp. 883 - 885
Main Authors Roy, B., Chambert, S., Lepoivre, M., Décout, J.-L.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis Group 01.10.2003
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Summary:Ribonucleosides and xylonucleosides bearing a disulfide function on the sugar ring were synthesized. Ribonucleosides belonging to the cytidine series were found to efficiently reduce dNTP pools in the human lymphoblastoïd CEM/SS cell line.
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content type line 23
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-120022677