Thionucleotides as Inhibitors of Ribonucleotide Reductase

Ribonucleosides and xylonucleosides bearing a disulfide function on the sugar ring were synthesized. Ribonucleosides belonging to the cytidine series were found to efficiently reduce dNTP pools in the human lymphoblastoïd CEM/SS cell line.

Saved in:
Bibliographic Details
Published inNucleosides, nucleotides & nucleic acids Vol. 22; no. 5-8; pp. 883 - 885
Main Authors Roy, B., Chambert, S., Lepoivre, M., Décout, J.-L.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis Group 01.10.2003
Subjects
Cytidine - analogs & derivatives
Cytidine - chemical synthesis
Cytidine - pharmacology
Disulfides
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Escherichia coli - enzymology
Indicators and Reagents
Ribonucleotide reductase
Ribonucleotide Reductases - antagonists & inhibitors
Thionucleosides
Thionucleotides - pharmacology
Xylose
Online AccessGet full text

Cover

More Information
Summary:Ribonucleosides and xylonucleosides bearing a disulfide function on the sugar ring were synthesized. Ribonucleosides belonging to the cytidine series were found to efficiently reduce dNTP pools in the human lymphoblastoïd CEM/SS cell line.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-120022677